Latest News


TOBeATPAIN Publication
‘Pain in Parkinson’s disease: new concepts in pathogenesis and treatment’
by Katarina Rukavina, Valentina Leta, Carolina Sportelli, Yazead Buhidma, Susan Duty, Marzia Malcangio, Kallol Ray Chaudhury
Volume 32, Number 4, August 2019
Current Opinion Neurology 2019, 32:579-588

www.co-neurology.com

DOI:10.1097/WCO.0000000000000711

Experimental Design and Practical Data Analysis in Positron Emission Tomography (PET) & Transferable Skills Training course

We are more than happy to announce that the first TOBeATPAIN scientific workshop took place at St Thomas’ Hospital in London during the first week of May and was a great success. The early stage researchers (ESRs) had the chance to meet for the first time and exchange ideas, discuss their project plans and organise future events including patient and public involvement activities.

The workshop, entitled “Experimental Design and Practical Data Analysis in Positron Emission Tomography (PET)”, was hosted by Professor Federico Turkheimer, Dr Mattia Veronese and other members of the molecular neuroimaging group at the Department of Neuroimaging at King’s College London (KCL). The primary focus of the workshop was to introduce the ESRs to the importance of functional imaging both for preclinical and clinical studies, lending weight to the analysis of the results by providing multiple hands-on sessions. Moreover, a key feature of the course was the in-depth presentations on the basics of IBM SPSS® and MATLAB ®, while also by thoroughly explaining the statistical basis of the PET analysis the instructors covered the whole process of setting up and analysing an experiment. Finally, the workshop was assisted by the book “Experimental Design and Practical Data Analysis in POSITRON EMISSION TOMOGRAPHY “and “Statistics without equations” written by Professor Turkheimer and Dr Veronese, so that the ESRs will have a point of reference before commencing on future experiments. Finally, the workshop was concluded by a Transferable Skills Training course given by Dr Aiofe Kiely from the Alzheimer’s Organisation entitled “Knowledge communication: Public engagement, fundraising and CSR”, where ESRs gained insight into writing public-oriented scientific articles raising awareness, and also learned the importance of communicating basic research to people that suffer from a pathological condition.

Before the completion of the first scientific workshop, the ESRs met the director of the programme Professor Marzia Malcangio, who has expressed her excitement to work with the eleven ESRs, thus underlining that the future of the TOBeATPAIN programme will involve collaborations among passionate scientists from different institutes around Europe aiming to understand and tackle pain. Undoubtedly, the first scientific workshop was only the beginning for the TOBeATPAIN researchers with more events to be announced.

By Georgios Sideris Lampretsas

TOBeATPAIN Early Stage Researcher 1

World Parkinson’s Day 12th April 2019 King’s College London Parkinson’s Centre of Excellence

On 12th of April a celebration for World Parkinson’s Day 2019 was hosted by the Parkinson Foundation Centre of Excellence at King’s and Professor K Ray Chaudhuri (TOBeATPAIN Horizon2020). The event showcased the width of translational and people-based Parkinson’s research that is being carried out in the campus within King’s Health Partners.
Internationally recognised scientists were invited to give inspiring talks about the non-motor symptoms of Parkinson’s disease. Among those distinguished speakers were Prof. Peter Jenner, Prof. Dag Aarsland, Dr Sarah Salvage and the organizer Prof. K Ray Chaudhuri. All of them are known worldwide for their expertise in translating basic and pre-clinical biomedical research into clinical findings that benefit patients. They showed us different ways of approaching important aspects of non-motor symptoms of Parkinson’s disease, including pain. It was very exciting to meet all of them and be aware of their important findings and research.
Furthermore, it is worthy of note that the event included patients with Parkinson Disease. They gave talks and described the experience of living with the disease. It was very touching to listen their stories. They motivated us to continue our research and try to understand the mechanisms underlying the non-motor symptoms of the disease and to investigate novel treatments.

By Joana Lama

TOBeATPAIN Early Stage Researcher 2

Projects


Individual Research Project 11

Rita Silva has been appointed as Early Stage Researcher 11 at Eli Lilly Co. Ltd.

Project Title: Neuroinflammation and CNS hyper-excitability in chronic pain and neurodegeneration mice models
Supervisor: Dr. Emanuele Sher (Eli Lilly)
Co-supervisor(s): Prof. M. Malcangio (KCL)

TOBeATPAIN Publication
‘Pain in Parkinson’s disease: new concepts in pathogenesis and treatment’

Katarina Rukavina, Valentina Leta, Carolina Sportelli, Yazead Buhidma, Susan Duty, Marzia Malcangio, Kallol Ray Chaudhury

Volume 32, Number 4, August 2019
Current Opinion Neurology 2019, 32:579-588

www.co-neurology.com

DOI:10.1097/WCO.0000000000000711

Individual Research Project 1

George Sideris Lampretsas has been appointed to the post of Early Stage Researcher 1 at King’s College London.

Project Title: Neuroinflammation and pain in Alzheimer’s disease
Supervisor: Prof. M. Malcangio (KCL) and Dr Matthew Howard (KCL, Neuroimaging)
Co-supervisor(s): Prof. C. Ballard (KCL, clinical) and Dr. K. Wafford (Eli Lilly)

Individual Research Project 2

Xhoana Lama has been appointed to the post of Early Stage Researcher 2 at King’s College London.

Project Title: Neuroinflammation and pain in Parkinson’s disease
Supervisor(s): Dr. Susan Duty (KCL), Prof. R. Chaudhuri (KCL, Clinical) and Prof. Steve Williams (KCL, Neuroimaging)
Co-supervisor(s): Prof. R. Chaudhuri (KCL, clinical) and Dr. M. O’Neill (Eli Lilly)

Individual Research Project 3

Silvia Fanton has been appointed to the post of Early Stage Researcher 3  at the Karolinska Institutet.

Project Title: Neuroinflammation and glia activation in fibromyalgia pain syndrome
Supervisor: Prof. E. Kosek (KI, clinical)
Co-supervisor(s): Prof C. Sommer (UKW, clinical) and Prof S. Paulie (Mabtech)

spinal cord microglia

Individual Research Project 4

Joana Menezes has been appointed to the post of Early Stage Researcher 4 at King’s College London.

Project Title: Role of brain and spinal cord micro(glia), TSPO and IL-8 in arthritis associated pain
Supervisor: Dr. Camilla Svensson (KI)
Co-supervisor(s): Prof H-G. Schaible (UKJ) and Dr. T. Olin (Kancera)

Role of microglia and macrophages and the CX3CL1-CX3CR1 pathway in arthritis-induced pain

Individual Research Project 5

Zerina Kurtovic has been appointed to the post of Early Stage Researcher 5 at Kancera AB

Project Title: Role of microglia and macrophages and the CX3CL1-CX3CR1 pathway in arthritis-induced pain
Supervisor: Dr. Thomas Olin (Kancera)
Co-supervisor(s): Dr. Camilla Svensson (KI)

euroinflammation and pain in a mouse model for Fabry disease

Individual Research Project 6

Jeiny Choconta has been appointed to the post of Early Stage Researcher 6 at Medizinische Universitat Innsbruck.

Project Title: Neuroinflammation and pain in a mouse model for Fabry disease
Supervisor: Prof. M. Kress (MUI)
Co-supervisor(s): Dr. M. Langeslag (MUI) and Prof. R. Chaudhuri (KCL, Clinical)

Mechanisms of spinal neuroinflammation and hyperexcitability in models of joint inflammation

Individual Research Project 7

Anutosh Roy has been appointed as Early Stage Researcher 7 at the Universitatsklinikum Jena.

Project Title: Mechanisms of spinal neuroinflammation and hyperexcitability in models of joint inflammation
Supervisor: Prof. H-Georg Schaible (UKJ)
Co-supervisor(s): Dr. A. Ebersberger (UKJ) and Dr. E. Sher (Eli Lilly)

Impact of neuroinflammation and neurodegeneration on brain and spinal cord

Individual Research Project 8

Fátima Gimeno Ferrer has been appointed as Early Stage Researcher 8 at the Universitatskinikum Jena.

Project Title: Impact of neuroinflammation and neurodegeneration on brain and spinal cord homeostasis: relevance to nociception
Supervisor: Prof. Frank Richter (UKJ)
Co-supervisor(s): Prof. Michaela Kress (MUI) and Prof. S. Paulie (Mabtech)

ESR 9 Neuroinflammation in pain and nerve degeneration and regeneration in peripheral neuropathies

Individual Research Project 9

Patricia Garzia Fernandez has been appointed as Early Stage Researcher 9 at the Universitaetsklinikum Wuerzburg.

Project Title: Neuroinflammation in pain and nerve degeneration and regeneration in peripheral neuropathies
Supervisor: Prof. Claudia Sommer (UKW, Clinical)
Co-supervisor(s): Dr. A. Ebersberger (UKJ) and Dr. S. Schoenbichler (Bionorica)

Assessment of medical marijuana bioactive substances in a mouse model of neuropathic pain

Individual Research Project 10

Christiana Dumbraveanu has been appointed as Early Stage Researcher 10 at Bionorica Research GMBH.

Project Title: Assessment of medical marijuana bioactive substances in a mouse model of neuropathic pain
Supervisor: Dipl.-Ing. A. Neumann (Bionorica)
Co-supervisor(s): Prof. M. Kress (MUI) and Prof. F. Turkheimer (KCL)

ESR 11 Neuroinflammation and CNS hyper-excitability in chronic pain and neurodegeneration
Eu flag logo blue and yellow

This project has received funding from the European Union’s Horizon 2020 research and innovation programme under the Marie Skłodowska-Curie Grant Agreement No 764860.